Nutraceuticals are dietary compounds which have a role in the balance of anabolic\nand catabolic signals in joints. Their regulatory function on homeostasis of cartilage metabolism\nnutraceuticals is increasingly considered for the management and, above all, the prevention\nof osteoarthritis (OA). OA is a degenerative disease characterized by cartilage and synovium\ninflammation that can cause joint stiffness, swelling, pain, and loss of mobility. It is a multifactorial\ndisease and, due to the great percentage of people suffering from it and the general increase in life\nexpectancy, OA is considered as one of the most significant causes of disability in the world. OA\nimpairs the structural integrity of articular cartilage that greatly depends on a balance between\nthe anabolic and catabolic processes which occur in chondrocytes and synovial fluid of the joints,\ntherefore the integration with nutraceutical compounds in diet increases the treatment options for\npatients with established OA beyond traditional rehabilitation, medications, and surgical strategies.\nIn our review, with respect to the current literature, we highlight some of many existing nutraceutical\ncompounds that could be used as integrators in a daily diet thanks to their easy availability, such as\nin olive oil, fish oil, and botanical extracts used as non-pharmacologic treatment.
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